GPC Nutritional Supplement - GlyceroPhosphoCholine INSTA-GEL 1200

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GPC Insta-Gel 1200

Unique squeezable Insta-Gel liquid tube. One dose/day each.
New Lower Price!

Each 4ml 1200 tube contains 1200 mg ELEMENTAL ("active load") GPC, because we use the pure liquid GPC in this product. We are the only company to do this and the only company to make this fully potentized product. One tube therefore gives you the exact amount used in the clinical trials--1200 mg.

For more information on GPC, see our documents:
GPC for Mind and Body

GPC Information

Parris Kidd, PhD, a foremost expert on brain nutrients, considers GPC (GlyceroPhosphoCholine) to be the premier brain nutrient for natural support of mental focus and brain repair.* GPC can sharpen attention in young healthy people, and athletes report it enhances mind-body coordination. GPC has a highly impressive clinical track record for supporting brain repair and ameliorating brain decline. It also outperformed several nutrients and drugs in controlled, head to head clinical trial comparisons.

Optimizing Mental Focus, Memory, and Brain Repair

GPC is a unique water-phase phospholipid that is a preferred dietary choline source, acetylcholine precursor, cell membrane phospholipid precursor, and systemic tissue protectant. In our experience, GlyceroPhosphoCholine works rapidly when given in a liquid form.* With this in mind, we are proud to offer the first liquid GPC supplement in the US that delivers a full 1200 mg of elemental GPC per dose. This is the exact dose used in the human clinical trials. These single-dose, Insta-Gel liquid tubes deliver GPC sublingually in an easily absorbed and pleasant-tasting liquid.

GPC works on the cellular level in our body as a:

Brain nourisher and revitalizer
Brain osmotic protector
Cell membrane building block
Choline and acetylcholine reservoir
Fertility support nutrient

What if there were one nutrient that could help you achieve better memory, focus, and concentration, and could also help maintain healthy brain function during aging? Glycerophosphocholine (GPC) is a powerful, natural compound that does all that and more. Over 20 clinical trials have been performed on GPC, and over 4,000 patients have been studied. The results show that it is one of the most clinically effective brain nutrients available today.

Optimizing Focus and Concentration

In two double-blinded trials, GPC has been found to restore memory and concentration in young people whose memory had been impaired by the sedative drug scopolamine.¹ Older adults showed improved reaction time when taking GPC, a sign that their brain is more alert and focused.² GPC also improves brain wave patterns associated with healthier brain aging.³

Providing Powerful Nutritional Support for Alzheimer’s and Other Forms of Dementia

A number of clinical trials have shown that using GPC for nutritional support may help the brain recover some of its functions that are lost during aging. GPC may even benefit those with dementia and Alzheimer’s disease.⁴ While it is not a cure for Alzheimer’s, a recently published double-blind trial documented GPC's benefits against mild to moderate Alzheimer's dementia. Twelve hundred milligrams of GPC per day orally was compared against placebo in 261 patients for 6 months. It proved significantly superior than placebo on all the measures used. The investigators noted that the GPC patients improved not just on cognition but in behavior and activities of daily living, “possibly improving patients’ and caregivers’ quality of life.”⁵

Supporting Healing After Stroke and Brain Injury

GPC is unquestionably the most important nutrient for anyone who has suffered a stroke or a brain injury. Five trials have been published in which GPC was successfully used to enhance stroke recovery in a total of nearly 3,000 patients. In each of these trials, GPC produced clinically meaningful results, providing healing benefits for stroke that are unique in the nutrient research literature. All of these studies used the same protocol: GPC injected intramuscularly at a dose of 1,000 mg per day for the first month, then taken orally at a dose of 1,200 mg per day for the following 5 months. In the first phase of treatment (intramuscular), neurological functions recovered by 20-30 percent. In the subsequent, oral phase of treatment, clinical improvement continued. The investigators concluded that GPC significantly helped more than 95 percent of the patients, and that it offered unique benefits against acute cerebrovascular disease.⁶

Protecting the Brain During Surgery

One of the dangers of major surgery is the anesthesia that accompanies it. Such anesthesia often leads to brain damage which can appear as memory loss and other forms of mental impairment. GPC has been researched in surgical patients, and has been found to have powerfully protective effects on the brain. In a double-blinded study of 20 patients undergoing open heart surgery, GPC significantly reduced the amount of memory loss and mental impairment that occurred in the daysand months following the procedure.⁷

How to Take GPC

Depending on which health condition you are supporting, start by taking 300-1200 mg in the morning. After 1-2 days, the dose can be increased if more mental focus or neuronal repair nutritional support is needed. Taking GPC within 6 hours of bedtime may make it harder to fall asleep at a normal hour. When taking GPC for the nutritional support of a diagnosed health condition, do so with the supervision of your health care practitioner.

GPC supplementation nutritionally supports:

focus, concentration, and recall
the speed and sharpness of mental processing
the revitalization of declining mental function
healthy mood levels, including positive attitude and sociability
the recovery of brain function following brain injury or circulatory deprivation
skeletal muscle integrity, including growth and regeneration
kidney and liver functions, including renewal and detoxification
fertility, both for sperm performance and for fertilization

Using GPC for Nutritional Support

General Health Maintenance ..... 300-600 mg
Optimizing Mental Focus ...... 600-1200 mg
Supporting the Brain Before and After Total Anesthesia ....1200 mg
Recovery from Stoke and Brain Injury .... 800-1200 mg
Alzheimer’s Disease and Dementia ....1200 mg

Frequently Asked Questions About GPC

When will I start feeling the benefits of GPC?

Most people begin to feel an increase in energy within 20 minutes, especially when taking GPC in its pure, liquid form. When taking the encapsulated or powdered version, allow 30-60 minutes for results to be felt.

What is the best form for oral delivery of GPC?

While GPC in powder form does work well for healthy patients, GPC in the pure liquid form appears to be assimilated more quickly by the body than powders or capsules. Because GPC is hygroscopic (waterattracting), it must be attached to a binder such as dicalcium phosphate in order to be made into a powder that can in turn be encapsulated. Chronically ill patients or those with compromised digestive function often do not do well with binders, and may have difficulty digesting and assimilating GPC in this form. For such chronically ill patients, GPC in pure liquid form is closer to the ideal.

Where does GPC come from?

GPC is naturally made from soy. Pure GPC liquid and powder is therefore suitable for vegetarians. GPC does not contain soy protein, so GPC does not cause allergic reactions such as can occur with soy protein and other soy products. Also note GPC is a unique, water-soluble phospholipid and that soy lecithin does not offer the same therapeutic effects of GPC.

Is GPC a natural component of our metabolism?

Yes. GPC belongs to an elite nutrient class known as “orthomolecular,” which means that GPC is completely natural to the body’s metabolism. This probably accounts for the great degree of safety associated with GPC.

How does GPC compare to other forms of choline such as lecithin and CDP choline?

GPC is superior to other choline forms including phosphatidyl choline for improving mental function according to a wide body of research.⁸ GPC has proven more effective in humans than CDP choline (cytidine diphosphocholine or citicoline) according to three controlled human clinical trials.⁹

Some research shows that GPC has been used by injection. Is this a more powerful way to use GPC?

Yes. This requires a prescription from your doctor, and can be filled by a compounding pharmacist. For those with serious brain damage, stroke, or severe memory problems, this route of administration is recommended if at all possible for the first four weeks of GPC therapy.

Does GPC raise human growth hormone levels?

A few human studies show that GPC when given by injection may have this effect. No studies on orally administered GPC and its effects on growth hormone have yet been published.

Are there any side effects from taking GPC?

Gastrointestinal upset can occur, but is rare. If GPC is taken in the 6 hours before bedtime, the mind can become so energized that it may be difficult to fall asleep.

References
1. Canal N, Franceschi M, Alberoni M, Castiglioni C, De Moliner P, Longoni A. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29(3):103-7.
2. Vezzetti V, Bettini R. Clinical and instrument evaluation of the effect of choline alfoscerate on cerebral decline. Presse Medicale 1992;5(141).
3. Locatelli M. Neurophysiological evaluation of alphaGPC (choline alfoscerate) by means of computerized electroencephalogram (CEEG). Le Basi Raz Ter 1990;20(79).
4. Parnetti L, Abate G, Bartorelli L, et al. Multicentre study of l-alphaglyceryl- phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type. Drugs Aging 1993;3(2):159-64.
5. De Jesus Moreno Moreno M. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther 2003;25(1):178-93.
6. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R. alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69.
7. Auteri A. Protecting the brain during heart surgery: treatment with choline alfoscerate. Le Basi Raz Ter 1993;23(123).
8. Parnetti L, Amenta F, Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mech Ageing Dev 2001;122(16):2041-55.
9. Di Perri R, Coppola G, Ambrosio LA, Grasso A, Puca FM, Rizzo M. A multicentre trial to evaluate the efficacy and tolerability of alphaglycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19(4):330-41.

Note that GPC is also referred to as choline alfoscerate or alphoscerate in the research literature.

(GlyceroPhosphoCholine) the Mind-Body Nutrient for Active Living and Healthy Aging, 2005, www.dockidd.com). A meta-analysis of GPC's cognitive benefits was published in 2001 by Parnetti and collaborators, as Choline alfoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data, in the journal Mechanisms of Ageing and Development, Volume 22, pages 2041-55.

Parnetti L, Amenta F, Gallai V. Choline alfoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mechs Ageing Dev 2001;22:2041-55.

PubMed Abstract: This paper has reviewed the documentation on the clinical efficacy of choline alphoscerate, a cholinergic precursor, considered as a centrally acting parasympathomimetic drug in dementia disorders and in acute cerebrovascular disease. Thirteen published clinical trials, examining in total 4054 patients, have evaluated the use of choline alphoscerate in various forms of dementia disorders of degenerative, vascular or combined origin, such as senile dementia of the Alzheimer's type (SDAT) or vascular dementia (VaD) and in acute cerebrovascular diseases, such as transitory ischemic attack (TIA) and stroke. Analysis has assessed the design of each study, in particular with respect to experimental design, number of cases, duration of treatment and tests used to evaluate drug clinical efficacy. Most of the ten studies performed in dementia disorders were controlled trials versus a reference drug or placebo. Overall, 1570 patients were assessed in these studies, 854 of which in controlled trials. As detected by validated and appropriate tests, such as Mini Mental State Evaluation (MMSE) in SDAT and Sandoz Clinical Assessment Geriatric (SCAG) in VaD, administration of choline alphoscerate significantly improved patient clinical condition. Clinical results obtained with choline alphoscerate were superior or equivalent to those observed in control groups under active treatment and superior to the results observed in placebo groups. Analysis stresses the clear internal consistency of clinical data gathered by different experimental situations on the drug effect, especially with regard to the cognitive symptoms (memory, attention) characterizing the clinical picture of adult-onset dementia disorders. The therapeutic usefulness of choline alphoscerate in relieving cognitive symptoms of chronic cerebral deterioration differentiates this drug from cholinergic precursors used in the past, such as choline and lecithin. Three uncontrolled trials were performed with choline alphoscerate in acute cerebrovascular stroke and TIA, totaling 2484 patients. The results of these trials suggest that this drug might favor functional recovery of patients with cerebral stroke and should be confirmed in future investigations aimed at establishing the efficacy of the drug in achieving functional recovery of patients with acute cerebrovascular disease.

Auteri A, et al. Protecting the brain during heart surgery: treatment with choline alfoscerate. Le Basi Raz Ter 1993;23:123-8.

Kidd PM. GlyceroPhosphoCholine (GPC), ortho-nutraceutical for active living and healthy aging. Townsend Letter for Doctors and Patients, April 2004. Update available at www.dockidd.com, as GPC (GlyceroPhosphoCholine), Mind-Body Nutrient for Active Living and Healthy Aging, 2005.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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